- SNK Arcade Classics Vol. 1
- SO. PUNNY.
- SOMA
- SONIC FAN GAME
- SONIC HEDGEHOG EXTRAVAGANZA
- SOVIET JUMP GAME STREAMING
- SO EXTREME
- SO MANY ZAMBOS
- SO METAL
- SO MUCH GUILT
- SPACE FIGHT
- SPACE POPE ROSS
- SPAIN SPAIN SPAIN
- SPOOKY Milk and Toilet Paper
- STAMPEDE
- STARBOMB Player Select OUT NOW!!
- STAR WARS: THE WORST RACER
- STOIC Jawful
- STOP TWITCHING
- STRAIGHT TO THE MOON SAVE THE PLANET
- SUCCESS!
- SUCH DRAMA
- SUPERHOT
- Sacre Bleu!
- Sacrilicious
- Sad Hoshi
- Sad Hoshi (Game Grumps Animated)
- Sad Hoshi (Journey to Silius)
- Sad Muggles
- Sad Sayori
- Sad and Angry
- Saddle Up
- Sadness Beyond All Else
- Saggy News
- Saint Hazel's Horsepital
- Sakura Santa
- Sakura Spirit
- Salamander County Public Television
- Salt Balls
- Salt and Sanctuary
- Salty Pieces
- Salving ALL Our Problems
- Sam and Max Hit the Road
- Same Sass Twice
- Same game, NEW PAIN!
- Samurai Gunn
- Samurai Gunn (episode)
- Samurai Pigs
- Sanctioned Buffoonery
- Sandstorm
- Sandy Lil Boots
- Sanic the Hodgegog
- Sank to the Bottom
- Santa's Christmas Solitaire
- Santa's House
- Santa's Perdition
- Santa's Story of Christmas
- Santa's Story of Christmas (episode)
- Santa's XMAS Caper (episode)
- Santa's Xmas Caper
- Santa's en fuego
- Santa Claus Saves the Earth
- Santa Claus got them CAKES doe!!!
- Santa Claus in Trouble
- Santa Claus in Trouble (episode)
- Santa Claus is Comin' to Town!
- Santa Claus is Comin' to Town! (episode)
- Santa Eats Children
- Santa’s Revenge
- Sara
- Sarcastic Encouragement
- Saria
- Sasquatch Stories
- Sass Fishing
- Sass and Anchovies
- Sassy Scimitars
- Sassy Statues
- Satan's Sodomy
- Saturday Night Slam Masters
- Saturday Night Slam Masters (episode)
- Saturn
- Saucy Pants
- Savage Dragon
- Save
- Save Every Seed
- Save My Daughter
- Save Yourself!
- Save the Chickens
- Save the Dog!
- Saved by the Bell
- Saved by the Burger
- Saved by the Save
- Savor the Flavor
- Say NO! More
- Say Your Prayers!
- Saying Words
- Scariest Tree Ever
- Scaring Crows
- Scarlett Mysteries: Cursed Child
- Scary Baboons
- Scary Barry
- Scary Box!
- Scary Cartoons
- Scary Chicken
- Scary Clowns
- Scary Eyes
- Scary Garbage
- Scary Hippos
- Scary Old Lady Bear
- Scary Snakes
- Scary Snowmen
- Scary Times
- Scent of a Woman
- Scheming!
- Schlong Ratio
- Schoolyard Fight
- Science is Neat
- Scissor Locked
- Scongebob Squarepants
- Scooby-Doo! Mystery Mayhem
- Scooby-Doo and the Cyber Chase
- Scooby-Doo and the Spooky Swamp
- Scooby Doo Mystery Mayhem with Rob Huebel
- Scorpion Supremacy
- Scrapper
- Scream Train
- Screencheat
- Screencheat (episode)
- Screw it, Katamari
- Screwing Nuts
- Scribbly Intimacy
- Scribey
- Scrubbing Away
- Scrubbing the Birdie
- Scuba Cats!
- Scuba Search
- Scuba Spantzz
- Sculpting Each Other w/ PLAY-DOH
- Scythes and Skills
- Scything in the Rain
- Sea Sick
- Sea Snakes
- Sea Speller
- Sea of Change
- Sea of Tears
- Sea of Toads
- Sea otter in a white wine reduction?!
- Seafoam Roam
- Sealing a Real Estate Deal with a KISS 💋
- Seamen
- Searchin' the Desert
- Searching the Tomb
- Seaside Séance
- Season 1 (Steam Train)
- Secret Area
- Secret Escape
- Secret Fires
- Secret HJs
- Secret Luigi
- Secret Puppies!
- Secret Secrets
- Secret of Mana
- Secret of the Magic Crystals
- Secret of the Magic Crystals (episode)
- Secrets 'n' Such
- Secrets Secrets
- Sector Z
- Security Troubles
- See the Gull
- Seeing Colors
- Seeing Fish
- Seeing Stars
- Seeking Knowledge
- Seeking Love
- Seen It Before
- Seen on TV!
- Seething with Anger
- Sega CD
- Sega Classics Collection
- Sega’s Bootleg Mario Party
- Sekiro: Shadows Die Twice
- Selective Incompetence
- Self Abuse (Not the Fun Kind)
- Self Care Session
- Self Defense Mechanism
- Self Five!
- Self Taught
- Seltas and Velocidrome BATTLE!
- Send that dang turtle to JAIL!
- Sengoku Basara: Samurai Heroes
- Sengoku Basara: Samurai Heroes (episode)
- Senile Goomba
- Sent From Above
- Separate Stomachs
- Sequelitis
- Sergeant Doctor
- Serious Business
- Serious Indigestion
- Serious NES
- Serious Penile Conversation
- Sesame Street Countdown
- Sesame Street Countdown (episode)
- Seth Rogan
- Setting the Standard
- Seven Asses.
- Seven Years
- Seven asses
- Sewer Adventure
- Sexy Mouse
- Sexy Raptors
- Sexy Widdle Baby
- Shadow's Shadow
- Shadow Corpse
- Shadow of the Colossus
- Shadow of the Tomb Raider
- Shadow the Hedgehog
- Shadows Over Camelot
- Shadows of the Damned
- Shaft Accidents
- Shaggy Time!
- Shake It
- Shaken Not Stirred
- Shaken Not Stirred (James Bond Jr.)
- Shaken Not Stirred (Skylanders: Superchargers)
- Shaking Bricks
- Shakira Shakira
- Shame!
- Shame and Fear
- Shammin' Around
- Shamu's Deep Sea Adventure With Special Guest Jacob Anderson
- Shamu's Deep Sea Adventures
- Shamu's Deep Sea Adventures (DS)
- Shamu's Deep Sea Adventures (GameCube)
- Shamu's Deep Sea Adventures (episode)
- Shantae and the Pirate's Curse
- Shaq-Fu
- Shaq-Fu (episode)
- Shards of Glass
- Sharing is Caring
- Sharing the Load
- Shark Attack!
- Shark Ice Cream
- Shark Shark
- Shark Simulator
- Shark Tales
- Shatterhand
- Shave and a Haircut
- Shaving Sheep
- Shawn Chatfield
- She's Got a Gun!
- She's a Toolhead, too.
- She's not messing with us, right?
- She Went That Way!
- She Will Be Mine
- She Won’t Talk to Me!
- Sheep
- Sheep (episode)
- Sheerow to Hero
- Shell Hell
- Shell Shocked!
- Shellfish Men
- Shenanigans
- Shenmue
- Sherman Fong
- Shhh...quiet...this is a BOSS BATTLE!
- Shifty Fish
- Shimmy Town
- Shin Godzilla
- ShineG In The Zombies
- Shine Time
- Ship Go Boom
- Ships Ahoy!
- Shipwrecked
- Shirtless Hero
- Shirtless Heroes
- Shock Troopers
- Shocking Pee
- Shoes!
- Shoocharu
- Shoot to Kill!
- Shootin' Koopies
- Shootin' Some Love
- Shootin Poopies
- Shooting Lemons
- Shooting down dumb arguments!
- Shooting the Sun!
- Shooty Fruity
- Shooty Fruity (episode)
- Shop 'til You Drop
- Shopping Spree
- Shopping Spree (Dead Rising - PART 43)
- Shore Shenanigans
- Shot Out Of A Cannon
- Shot Through the Heart
- Shot and Missed
- Shot in the Dark
- Shot out of a CANNON
- Shotgun Diarrhea
- Shotgun King: The Final Checkmate
- Shoulda Saved
- Shovel Knight
- Shovel Knight (episode)
- Shovel Ninjas
- Show Me Your Back!
- Show Time!
- Show us your MATH D%©K!!!
- Showcase Showdown
- Shower With Your Dad Simulator 2015
- Shower With Your Dad Simulator 2015 (episode)
- Showing The Enlargement
- Showing the Goods
- Shredding Shell
- Shrek's Carnival Craze
- Shrek Forever After
- Shrek Forever After (episode)
- Shrek Smash n' Crash Racing
- Shrek Sucks
- Shrek Super Party
- Shrine of Gamelon
- Shroooms!
- Shut-Eye
- Shut-Eye (episode)
- Shutup, Robot Cowboy!
- Sick Bird
- Sidle On Up
- Silent AND Deadly
- Silent Hill: Play Novel
- Silent Hill: Play Novel (episode)
- Silent Hill: Shattered Memories
- Silent Hill 4: The Room
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