- Spice World (episode)
- Spider-Man: Homecoming
- Spider-Man (2018)
- Spider-Man 3
- Spider-Man 3 The Game
- Spider-Man and Venom: Maximum Carnage
- Spider-Man and Venom: Maximum Carnage (episode)
- SpiderHeck
- Spider Pool
- Spiders Galore!
- Spiders with lightsabers: The Game
- Spidey Snaps
- Spike Balls
- Spike It!
- Spikey Death Awaits
- Spiky Brain Suckin' Pricks
- Spiky Dudes Everywhere
- Spills and Thrills
- Spin the Wheel
- Spinnaker
- Spinning for Days
- Spirit Questing
- Spirits Gone Wild
- Spittin' Out Babies
- Spitting Rhymes
- Splatoon 2
- Splatoon 2 (The G Club)
- Splatoonfield
- Splattered Egg
- Splatterhouse: Wanpaku Graffiti
- Splattin' Up A Storm
- Splooging
- Spoiled Kid Takes Tumble
- Spoiler Owl
- SpongeBob SquarePants: Battle for Bikini Bottom
- Spooky Cats
- Spooky Cats (episode)
- Spooky Corner
- Spooky Fog
- Spooky Halloween Adventures!
- Spooky Pirate Boss
- Spooky Pirate Cave
- Spooky Robots
- Spooky Scary
- Spooky Spelling
- Spooky Trails
- Spoompls
- Spooning
- Spore
- Spork!
- Sports Man Dan
- Spot The Difference: Party! (episode)
- Spot The Differences: Party!
- Spotting Tessie
- Sprang Break
- Spray
- Spray and Pray
- Spraying Love
- Spreading Christmas cheer with a shotgun
- Spreading Positivity
- Spreading the Jam
- Spring Break
- Spring Break (Imagine Party Babyz)
- Spring Break (Super Mario Maker)
- Spring Break (Super Metroid)
- Spring Breeze ADVENTURES!
- Spring Breeze ADVENTURES!: Script
- Spring to Action
- Springy Anger
- Sprouse
- Sprung
- Squandered Chicken
- Squareface
- Squareface (episode)
- Squares
- Squaresville
- Squeezin' The Odds
- Squidward
- Squidward- PLEASE NO!
- Squiggly Robot Man
- Squirrel Boys
- Squirrel Key
- Squished and Crushed
- Sr677 (Mii)
- Stage Fright
- Stairway to Nowhere
- Stakes are Low
- Stallion Horses
- Stamper
- Standing On Three B-Holes
- Standing Tall
- Standing in the Doorway
- Stanley: The Search for Dr. Livingston
- StarTropics
- Star Child
- Star Crash or PC Crash?
- Star Farting
- Star Fox
- Star Fox 64
- Star Fox with the SUPER GUITAR BROS
- Star Quarterback Arin
- Star Stealer
- Star Stealing Schmucks
- Star Trek Legacy
- Star Trek Legacy (episode)
- Star Wars: Masters of Teräs Käsi
- Star Wars: Masters of Teräs Käsi (episode)
- Star Wars: Rogue Squadron
- Star Wars: Rogue Squadron (episode)
- Star Wars: Super Bombad Racing
- Star Wars Battlefront
- Star Wars Battlefront with Special Guest Claudio Sanchez
- Star Wars Episode I: Jedi Power Battles
- Star Wars Episode I: Racer
- Star Wars Episode I: The Phantom Menace
- Star Wars Episode I The Phantom Menace (episode)
- Star Wars Jedi Power Battles
- Star Wars Opinions
- Star Wolf
- Starbomb
- Stardew Valley
- Stardew Valley (Nintendo Switch)
- Stardew Valley (PC)
- Stargazer Christmas
- Stargazer Christmas (episode)
- Staring Contest
- Staring Down The Barrel Of A Weiner
- Starmie and You
- Starry Stardom
- Stars All Around
- Stars and Magic and Blood
- Starting Fires
- Starting Small
- Starting an Episode
- Starting off strong
- Starwhal
- Starwhal (episode)
- State Pride
- Statue Slapper
- Stay Away!
- Stay Down!
- Stay Frosty
- Stay in the Cage!
- Stay the Course!
- Stayin' Alive
- Staying Basic
- Stealing Apples
- Stealing a Credit Card
- Stealth Mode Initiated
- Steam Boats
- Steam Rolled
- Steam Rolled Intro
- Steam Sleigh
- Steam Train
- Steam Train/Gallery
- Steam Train Intro
- Steam Train T-SHIRT! ON SALE! CHOO CHOO! YAY!!
- Steam Train T-Shirt ALTERNATE TAKE!
- Steamin' Potatoes
- Steamy Conversation
- Step Back!
- Step By Step
- Step On It
- Step on me, Sentinel Queen!
- Stephanie Gets Inspired
- Stephen's Sausage Roll
- Stepping Up
- Steve-O
- Stevecraft
- Stew's On
- Stick Fight: The Game
- Stick Wizards
- Stick in the Mud
- Sticking a Pole in It
- Sticky Dreams
- Still Shreddin'
- Still in My Pajamas!
- Sting Like a Bee
- Stinkin' Thinkin'
- Stinky Flower
- Stinky Time
- Stitches
- Stockholm Syndrome
- Stocking Up
- Stolen From The World
- Stone Talus
- Stop, Drop and Roll!
- Stop Strokin' It
- Stop With the Moving
- Stop Yelling at Me!
- Stop and Go
- Stop and Go Traffic
- Stop the Rocket
- Stopping Time
- Storage Room Sneaking
- Storm the Castle
- Stout Train
- Straight Down Death
- Straight Up Ate
- Straight Up Dog Anime
- Straight Up Loser
- Strange Accents
- Strange Situation
- Stranger Danger
- Strangest Interview
- Street Fighter: The Movie
- Street Fighter V
- Strength in Peanuts
- Stretch Panic
- Strider
- Strider 2
- Strike the Earth!
- Strike the Earth! (Shovel Knight Co-Op - PART 5)
- Striking A Deal?
- Striking a Chord
- Stripes, Spots or Circles?
- Strokin' Out
- Struggling
- Struggling to perform BASIC HUMAN FUNCTIONS!
- Stuck in the Swamp
- Stuck on the Butt
- Study Time!
- Stuff of Nightmares
- Stuffed Birdies
- Stuffed Donkey Rampage!
- Stumble Guys
- Stumped
- Stumping the Trump
- Stun Seed LICKING
- Stunned Silence
- Stupid Amber
- Stupid Clam
- Stupid Hard
- Stupid Tired
- Stupid and Young
- Submerged Elevator
- Subnautica
- Subreddit
- Subs and Dubs
- Subway to HELL
- Success and Stuff
- Such A Friendly Bear
- Such a Downer
- Suck It
- Suck the Blood
- Sucker for Love: First Date
- Suckin' Demons
- Sudden Death!
- Sudden Decompression
- Suddenly this is game is too stressful
- Suffering
- Suffering and Bananas
- Sufficiently Awkward
- Sugar Rush
- Suggestive Themes
- Suit Yourself
- Summoned Souls
- Summoning the COMEDEITY
- Sun Stroke!
- Sunder
- Sunken in the Snow
- Sunny Day
- SuperMega
- Super Adventure Island
- Super Agony
- Super Amazing Wagon Adventure Turbo
- Super Balls
- Super Best Friends
- Super Big Apples
- Super Bomberman 2
- Super Bomberman 2 (episode)
- Super Bomberman R
- Super Bonk
- Super Brophy Brothers
- Super Bull
- Super Bunny Man
- Super C
- Super Candy
- Super Castlevania IV
- Super Cat!
- Super Duper Computer
- Super Duper Madness
- Super Fire
- Super Galdelic Hour
- Super Ghouls 'n Ghosts
- Super Hammer
- Super Ineffective
- Super Jacked
- Super Jazzed
- Super Life of Pixel
- Super Mario 3D World
- Super Mario 3D World + Bowser’s Fury
- Super Mario 64
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